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The Rise of Cryo-EM Among Structural Characterization Methods: NMR, X-Ray Crystallography

Characterization plays a comprehensive role throughout discovery. For structural biologists, this entails gaining a better understanding of biophysical and dynamic properties relative to their research molecules. While various disciplines continue to help innovate methods used for structural studies-the recent introduction of cryo-electron microscopy (cryo-EM) has been a significant addition to the experimental workflow. In this note, we review and compare primary methods for structural characterization, while exploring the true application potential for Cryo-EM.

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