E-Selectin

Recombinant ID:

3305

Request Datasheet

Gene of Interest

Gene Synonyms:

SELE;ELAM1

Protein Names:

E-selectin (CD62 antigen-like family member E) (Endothelial leukocyte adhesion molecule 1) (ELAM-1) (Leukocyte-endothelial cell adhesion molecule 2) (LECAM2) (CD antigen CD62E)

Accession Data

Organism:

Homo sapiens (Human)

Mass (kDa):

66655

Length (aa):

610

Sequence:

MIASQFLSALTLVLLIKESGAWSYNTSTEAMTYDEASAYCQQRYTHLVAIQNKEEIEYLNSILSYSPSYYWIGIRKVNNVWVWVGTQKPLTEEAKNWAPGEPNNRQKDEDCVEIYIKREKDVGMWNDERCSKKKLALCYTAACTNTSCSGHGECVETINNYTCKCDPGFSGLKCEQIVNCTALESPEHGSLVCSHPLGNFSYNSSCSISCDRGYLPSSMETMQCMSSGEWSAPIPACNVVECDAVTNPANGFVECFQNPGSFPWNTTCTFDCEEGFELMGAQSLQCTSSGNWDNEKPTCKAVTCRAVRQPQNGSVRCSHSPAGEFTFKSSCNFTCEEGFMLQGPAQVECTTQGQWTQQIPVCEAFQCTALSNPERGYMNCLPSASGSFRYGSSCEFSCEQGFVLKGSKRLQCGPTGEWDNEKPTCEAVRCDAVHQPPKGLVRCAHSPIGEFTYKSSCAFSCEEGFELHGSTQLECTSQGQWTEEVPSCQVVKCSSLAVPGKINMSCSGEPVFGTVCKFACPEGWTLNGSAARTCGATGHWSGLLPTCEAPTESNIPLVAGLSAAGLSLLTLAPFLLWLRKCLRKAKKFVPASSCQSLESDGSYQKPSYIL

Proteomics (Proteome ID):

E-selectin (CD62 antigen-like family member E) (Endothelial leukocyte adhesion molecule 1) (ELAM-1) (Leukocyte-endothelial cell adhesion molecule 2) (LECAM2) (CD antigen CD62E)

Proteomics (Chromosome):

UP000005640

Mass Spectrometry:

N/A

Function [CC]:

Cell-surface glycoprotein having a role in immunoadhesion. Mediates in the adhesion of blood neutrophils in cytokine-activated endothelium through interaction with SELPLG/PSGL1. May have a role in capillary morphogenesis. {ECO:0000269|PubMed:1689848, ECO:0000269|PubMed:28011641}.

Metal Binding:

METAL 101 101 Calcium. {ECO:0000244|PDB:1ESL, ECO:0000244|PDB:4C16, ECO:0000244|PDB:4CSY, ECO:0000269|PubMed:26117840}.; METAL 103 103 Calcium. {ECO:0000244|PDB:1ESL, ECO:0000244|PDB:1G1T, ECO:0000244|PDB:4C16, ECO:0000244|PDB:4CSY, ECO:0000269|PubMed:11081633, ECO:0000269|PubMed:26117840}.; METAL 109 109 Calcium. {ECO:0000244|PDB:4C16, ECO:0000244|PDB:4CSY, ECO:0000269|PubMed:11081633, ECO:0000269|PubMed:26117840}.; METAL 126 126 Calcium. {ECO:0000244|PDB:1ESL, ECO:0000244|PDB:1G1T, ECO:0000244|PDB:4C16, ECO:0000244|PDB:4CSY, ECO:0000269|PubMed:11081633, ECO:0000269|PubMed:26117840}.; METAL 127 127 Calcium. {ECO:0000244|PDB:1ESL, ECO:0000244|PDB:1G1T, ECO:0000244|PDB:4C16, ECO:0000244|PDB:4CSY, ECO:0000269|PubMed:11081633, ECO:0000269|PubMed:26117840}.

Site:

N/A

Tissue Specificity:

N/A

Disease:

N/A

Mutagenesis:

MUTAGEN 109 109 E->D: Decreased adhesion to cells expressing SELPLG. {ECO:0000269|PubMed:28011641}.

Reagent Data

Name:

E-selectin (CD62 antigen-like family member E) (Endothelial leukocyte adhesion molecule 1) (ELAM-1) (Leukocyte-endothelial cell adhesion molecule 2) (LECAM2) (CD antigen CD62E)

Class:

Subcategory:

Recombinant

Molecular Weight:

Source:

Species:

Human

Amino Acid Sequence:

Inquire

Tag:

Format:

Lyophilized

Formulation:

Sterile-filtered colorless solution

Formulation Concentration:

1mg/ml

Buffer Volume:

Standard

Buffer Solution:

PBS

pH:

7.4-7.5

Stabilizers

NaCl:

Null

Metal Chelating Agents

EDTA:

Null

Purity:

> 98%

Determined:

SDS-PAGE

Stained:

Inquire

Validated:

RP-HPLC

Sample Handling

Storage:

-20°C

Stability:

This bioreagent is stable at 4°C (short-term) and -70°C(long-term). After reconstitution, sample may be stored at 4°C for 2-7 days and below -18°C for future use.

Preparation:

Reconstitute in sterile distilled H2O to no less than 100ug/ml; dilute reconstituted stock further in other aqueous solutions if needed. Please review COA for lot-specific instructions. Final measurements should be determined by the end-user for optimal performance.