C-Reactive Protein

Gene Synonyms:

Protein Names:

Organism:

Homo sapiens (Human)

Mass (kDa):

25039

Length (aa):

224

Sequence:

MEKLLCFLVLTSLSHAFGQTDMSRKAFVFPKESDTSYVSLKAPLTKPLKAFTVCLHFYTELSSTRGYSIFSYATKRQDNEILIFWSKDIGYSFTVGGSEILFEVPEVTVAPVHICTSWESASGIVEFWVDGKPRVRKSLKKGYTVGAEASIILGQEQDSFGGNFEGSQSLVGDIGNVNMWDFVLSPDEINTIYLGGPFSPNVLNWRALKYEVQGEVFTKPQLWP

Proteomics (Proteome ID):

C-reactive protein [Cleaved into: C-reactive protein(1-205)]

Proteomics (Chromosome):

UP000005640

Mass Spectrometry:

Mass=23028; Method=MALDI; Range=19-224; Evidence={ECO:0000269|Ref.15}; Mass=22930; Method=MALDI; Range=19-223; Evidence={ECO:0000269|Ref.15};

Function [CC]:

Displays several functions associated with host defense: it promotes agglutination, bacterial capsular swelling, phagocytosis and complement fixation through its calcium-dependent binding to phosphorylcholine. Can interact with DNA and histones and may scavenge nuclear material released from damaged circulating cells.

Metal Binding:

METAL 78 78 Calcium 1. {ECO:0000255|PROSITE-ProRule:PRU01172}.; METAL 79 79 Calcium 1. {ECO:0000255|PROSITE-ProRule:PRU01172}.; METAL 156 156 Calcium 1. {ECO:0000255|PROSITE-ProRule:PRU01172}.; METAL 156 156 Calcium 2. {ECO:0000255|PROSITE-ProRule:PRU01172}.; METAL 157 157 Calcium 1; via carbonyl oxygen. {ECO:0000255|PROSITE-ProRule:PRU01172}.; METAL 158 158 Calcium 1. {ECO:0000255|PROSITE-ProRule:PRU01172}.; METAL 158 158 Calcium 2. {ECO:0000255|PROSITE-ProRule:PRU01172}.; METAL 168 168 Calcium 2. {ECO:0000255|PROSITE-ProRule:PRU01172}.

Site:

N/A

Tissue Specificity:

Found in plasma.

Disease:

N/A

Mutagenesis:

N/A

Name:

C-reactive protein [Cleaved into: C-reactive protein(1-205)]

Class:

Subcategory:

Recombinant

Source:

Species:

Human

Amino Acid Sequence:

Tag:

Format:

Lyophilized

Formulation:

Sterile-filtered colorless solution

Formulation Concentration:

1mg/ml

Buffer Volume:

Standard

Buffer Solution:

PBS

pH:

7.4-7.5

NaCl:

Null

EDTA:

Null

Purity:

> 98%

Determined:

SDS-PAGE

Stained:

Inquire

Validated:

RP-HPLC

Storage:

-20°C

Stability:

This bioreagent is stable at 4°C (short-term) and -70°C(long-term). After reconstitution, sample may be stored at 4°C for 2-7 days and below -18°C for future use.

Preparation:

Reconstitute in sterile distilled H2O to no less than 100ug/ml; dilute reconstituted stock further in other aqueous solutions if needed. Please review COA for lot-specific instructions. Final measurements should be determined by the end-user for optimal performance.