PD-L2

Gene Synonyms:

Protein Names:

Organism:

Mus musculus (Mouse)

Mass (kDa):

27820

Length (aa):

247

Sequence:

MLLLLPILNLSLQLHPVAALFTVTAPKEVYTVDVGSSVSLECDFDRRECTELEGIRASLQKVENDTSLQSERATLLEEQLPLGKALFHIPSVQVRDSGQYRCLVICGAAWDYKYLTVKVKASYMRIDTRILEVPGTGEVQLTCQARGYPLAEVSWQNVSVPANTSHIRTPEGLYQVTSVLRLKPQPSRNFSCMFWNAHMKELTSAIIDPLSRMEPKVPRTWPLHVFIPACTIALIFLAIVIIQRKRI

Proteomics (Proteome ID):

Programmed cell death 1 ligand 2 (PD-1 ligand 2) (PD-L2) (PDCD1 ligand 2) (Programmed death ligand 2) (Butyrophilin B7-DC) (B7-DC) (CD antigen CD273)

Proteomics (Chromosome):

UP000000589

Mass Spectrometry:

N/A

Function [CC]:

Involved in the costimulatory signal essential for T-cell proliferation and IFNG production in a PDCD1-independent manner. Interaction with PDCD1 inhibits T-cell proliferation by blocking cell cycle progression and cytokine production. {ECO:0000269|PubMed:11224527, ECO:0000269|PubMed:11283156, ECO:0000269|PubMed:12719480}.

Metal Binding:

N/A

Site:

N/A

Tissue Specificity:

Expressed in immature and mature bone marrow-derived dendritic cells and splenic dendritic cells. Highly expressed in placenta, liver and weakly expressed in heart, spleen, lymph nodes and thymus. Also expressed in some tumor cell lines of lymphoid origin. {ECO:0000269|PubMed:11224527, ECO:0000269|PubMed:11283156}.

Disease:

N/A

Mutagenesis:

MUTAGEN 33 33 D->S: No effect on PDCD1 binding. {ECO:0000269|PubMed:12719480}.; MUTAGEN 39 39 S->Y: No effect on PDCD1 binding. {ECO:0000269|PubMed:12719480}.; MUTAGEN 41 41 E->S: No effect on PDCD1 binding. {ECO:0000269|PubMed:12719480}.; MUTAGEN 56 56 R->S: Significantly reduces the binding to PDCD1. {ECO:0000269|PubMed:12719480}.; MUTAGEN 58 58 S->Y: No effect on PDCD1 binding. {ECO:0000269|PubMed:12719480}.; MUTAGEN 65 65 D->S: No effect on PDCD1 binding. {ECO:0000269|PubMed:12719480}.; MUTAGEN 67 67 S->Y: Significantly reduces the binding to PDCD1. {ECO:0000269|PubMed:12719480}.; MUTAGEN 71 71 E->S: Significantly reduces the binding to PDCD1. {ECO:0000269|PubMed:12719480}.; MUTAGEN 72 72 R->S: No effect on PDCD1 binding. {ECO:0000269|PubMed:12719480}.; MUTAGEN 84 84 K->S: No effect on PDCD1 binding. {ECO:0000269|PubMed:12719480}.; MUTAGEN 88 88 H->A: No effect on PDCD1 binding. {ECO:0000269|PubMed:12719480}.; MUTAGEN 101 101 R->S: Significantly reduces the binding to PDCD1. {ECO:0000269|PubMed:12719480}.; MUTAGEN 103 103 L->A: No effect on PDCD1 binding. {ECO:0000269|PubMed:12719480}.; MUTAGEN 105 105 I->A: Abolishes the binding to PDCD1. {ECO:0000269|PubMed:12719480}.; MUTAGEN 111 111 D->S: Abolishes the binding to PDCD1. Costimulates proliferation and IFNG production of T-cells. {ECO:0000269|PubMed:12719480}.; MUTAGEN 113 113 K->S: Abolishes the binding to PDCD1. Costimulates proliferation and IFNG production of T-cells. {ECO:0000269|PubMed:12719480}.; MUTAGEN 116 116 T->Y: No effect on PDCD1 binding. {ECO:0000269|PubMed:12719480}.

Name:

Programmed cell death 1 ligand 2 (PD-1 ligand 2) (PD-L2) (PDCD1 ligand 2) (Programmed death ligand 2) (Butyrophilin B7-DC) (B7-DC) (CD antigen CD273)

Class:

Subcategory:

Recombinant

Source:

Species:

Mouse

Amino Acid Sequence:

Tag:

Format:

Lyophilized

Formulation:

Sterile-filtered colorless solution

Formulation Concentration:

1mg/ml

Buffer Volume:

Standard

Buffer Solution:

PBS

pH:

7.4-7.5

NaCl:

Null

EDTA:

Null

Purity:

> 98%

Determined:

SDS-PAGE

Stained:

Inquire

Validated:

RP-HPLC

Storage:

-20°C

Stability:

This bioreagent is stable at 4°C (short-term) and -70°C(long-term). After reconstitution, sample may be stored at 4°C for 2-7 days and below -18°C for future use.

Preparation:

Reconstitute in sterile distilled H2O to no less than 100ug/ml; dilute reconstituted stock further in other aqueous solutions if needed. Please review COA for lot-specific instructions. Final measurements should be determined by the end-user for optimal performance.