CCL3

Gene Synonyms:

Protein Names:

Organism:

Homo sapiens (Human)

Mass (kDa):

10085

Length (aa):

92

Sequence:

MQVSTAALAVLLCTMALCNQFSASLAADTPTACCFSYTSRQIPQNFIADYFETSSQCSKPGVIFLTKRSRQVCADPSEEWVQKYVSDLELSA

Proteomics (Proteome ID):

C-C motif chemokine 3 (G0/G1 switch regulatory protein 19-1) (Macrophage inflammatory protein 1-alpha) (MIP-1-alpha) (PAT 464.1) (SIS-beta) (Small-inducible cytokine A3) (Tonsillar lymphocyte LD78 alpha protein) [Cleaved into: MIP-1-alpha(4-69) (LD78-alpha(4-69))]

Proteomics (Chromosome):

UP000005640

Mass Spectrometry:

N/A

Function [CC]:

Monokine with inflammatory and chemokinetic properties. Binds to CCR1, CCR4 and CCR5. One of the major HIV-suppressive factors produced by CD8+ T-cells. Recombinant MIP-1-alpha induces a dose-dependent inhibition of different strains of HIV-1, HIV-2, and simian immunodeficiency virus (SIV). {ECO:0000269|PubMed:8525373}.

Metal Binding:

N/A

Site:

SITE 40 40 Involved in GAG binding.; SITE 68 68 Involved in GAG binding.; SITE 70 70 Involved in GAG binding.

Tissue Specificity:

N/A

Disease:

N/A

Mutagenesis:

MUTAGEN 40 40 R->A: Slightly reduces heparin binding. {ECO:0000269|PubMed:9092555}.; MUTAGEN 49 49 D->A: Reduces self-association; in BB-10010: Improved pharmaceutical properties. {ECO:0000269|PubMed:10347159, ECO:0000269|PubMed:8541527}.; MUTAGEN 68 68 R->A: Strongly reduces heparin binding. {ECO:0000269|PubMed:9092555}.; MUTAGEN 70 70 R->A: Reduces heparin binding. {ECO:0000269|PubMed:9092555}.; MUTAGEN 89 89 E->A: Reduces self-association. {ECO:0000269|PubMed:10347159}.

Name:

C-C motif chemokine 3 (G0/G1 switch regulatory protein 19-1) (Macrophage inflammatory protein 1-alpha) (MIP-1-alpha) (PAT 464.1) (SIS-beta) (Small-inducible cytokine A3) (Tonsillar lymphocyte LD78 alpha protein) [Cleaved into: MIP-1-alpha(4-69) (LD78-alpha(4-69))]

Class:

Subcategory:

Recombinant

Source:

Species:

Human

Amino Acid Sequence:

Tag:

Format:

Lyophilized

Formulation:

Inquire

Formulation Concentration:

Inquire

Buffer Volume:

Standard

Buffer Solution:

PBS

pH:

7.4-7.5

NaCl:

Null

EDTA:

Null

Purity:

> 97%

Determined:

SDS-PAGE

Stained:

Migration Assay

Validated:

Inquire

Storage:

-20°C

Stability:

This bioreagent is stable at 4°C (short-term) and -70°C(long-term). After reconstitution, sample may be stored at 4°C for 2-7 days and below -18°C for future use.

Preparation:

Reconstitute in sterile distilled H2O to no less than 100ug/ml; dilute reconstituted stock further in other aqueous solutions if needed. Please review COA for lot-specific instructions. Final measurements should be determined by the end-user for optimal performance.