Cystatin SN

Gene Synonyms:

Protein Names:

Organism:

Homo sapiens (Human)

Mass (kDa):

16388

Length (aa):

141

Sequence:

MAQYLSTLLLLLATLAVALAWSPKEEDRIIPGGIYNADLNDEWVQRALHFAISEYNKATKDDYYRRPLRVLRARQQTVGGVNYFFDVEVGRTICTKSQPNLDTCAFHEQPELQKKQLCSFEIYEVPWENRRSLVKSRCQES

Proteomics (Proteome ID):

Cystatin-SN (Cystain-SA-I) (Cystatin-1) (Salivary cystatin-SA-1)

Proteomics (Chromosome):

UP000005640

Mass Spectrometry:

Mass=14303.1553; Mass_error=0.0675; Method=Electrospray; Range=21-141; Evidence={ECO:0000269|PubMed:20189825}; Mass=14319.171; Mass_error=0.0523; Method=Electrospray; Range=21-141; Note=Variant Leu-31.; Evidence={ECO:0000269|PubMed:20189825};

Function [CC]:

Human saliva appears to contain several cysteine proteinase inhibitors that are immunologically related to cystatin S but that differ in their specificity due to amino acid sequence differences. Cystatin SN, with a pI of 7.5, is a much better inhibitor of papain and dipeptidyl peptidase I than is cystatin S, although both inhibit ficin equally well.

Metal Binding:

N/A

Site:

SITE 32 32 Reactive site.

Tissue Specificity:

Expressed in submandibular and sublingual saliva but not in parotid saliva (at protein level). Expressed in saliva, tears, urine and seminal fluid. {ECO:0000269|PubMed:20189825}.

Disease:

N/A

Mutagenesis:

N/A

Name:

Cystatin-SN (Cystain-SA-I) (Cystatin-1) (Salivary cystatin-SA-1)

Class:

Subcategory:

Recombinant

Source:

Species:

Human

Amino Acid Sequence:

Tag:

Format:

Lyophilized

Formulation:

Sterile-filtered colorless solution

Formulation Concentration:

1mg/ml

Buffer Volume:

Standard

Buffer Solution:

PBS

pH:

7.4-7.5

NaCl:

Null

EDTA:

Null

Purity:

> 98%

Determined:

SDS-PAGE

Stained:

Inquire

Validated:

RP-HPLC

Storage:

-20°C

Stability:

This bioreagent is stable at 4°C (short-term) and -70°C(long-term). After reconstitution, sample may be stored at 4°C for 2-7 days and below -18°C for future use.

Preparation:

Reconstitute in sterile distilled H2O to no less than 100ug/ml; dilute reconstituted stock further in other aqueous solutions if needed. Please review COA for lot-specific instructions. Final measurements should be determined by the end-user for optimal performance.