CEACAM-8

Recombinant ID:

3274

Request Datasheet

Gene of Interest

Gene Synonyms:

CEACAM8;CGM6

Protein Names:

Carcinoembryonic antigen-related cell adhesion molecule 8 (CD67 antigen) (Carcinoembryonic antigen CGM6) (Non-specific cross-reacting antigen NCA-95) (CD antigen CD66b)

Accession Data

Organism:

Homo sapiens (Human)

Mass (kDa):

38154

Length (aa):

349

Sequence:

MGPISAPSCRWRIPWQGLLLTASLFTFWNPPTTAQLTIEAVPSNAAEGKEVLLLVHNLPQDPRGYNWYKGETVDANRRIIGYVISNQQITPGPAYSNRETIYPNASLLMRNVTRNDTGSYTLQVIKLNLMSEEVTGQFSVHPETPKPSISSNNSNPVEDKDAVAFTCEPETQNTTYLWWVNGQSLPVSPRLQLSNGNRTLTLLSVTRNDVGPYECEIQNPASANFSDPVTLNVLYGPDAPTISPSDTYYHAGVNLNLSCHAASNPPSQYSWSVNGTFQQYTQKLFIPNITTKNSGSYACHTTNSATGRNRTTVRMITVSDALVQGSSPGLSARATVSIMIGVLARVALI

Proteomics (Proteome ID):

Carcinoembryonic antigen-related cell adhesion molecule 8 (CD67 antigen) (Carcinoembryonic antigen CGM6) (Non-specific cross-reacting antigen NCA-95) (CD antigen CD66b)

Proteomics (Chromosome):

UP000005640

Mass Spectrometry:

N/A

Function [CC]:

Cell surface glycoprotein that plays a role in cell adhesion in a calcium-independent manner (PubMed:8776764, PubMed:2022629, PubMed:11590190). Mediates heterophilic cell adhesion with other carcinoembryonic antigen-related cell adhesion molecules, such as CEACAM6 (PubMed:8776764, PubMed:2022629, PubMed:11590190). Heterophilic interaction with CEACAM8 occurs in activated neutrophils (PubMed:8776764). {ECO:0000269|PubMed:11590190, ECO:0000269|PubMed:2022629, ECO:0000269|PubMed:8776764}.

Metal Binding:

N/A

Site:

N/A

Tissue Specificity:

Expressed in leukocytes of chronic myeloid Leukemia patients and bone marrow.

Disease:

N/A

Mutagenesis:

MUTAGEN 40 45 AVPSNA->STPFNV: No effect on heterophilic cell adhesion. {ECO:0000269|PubMed:11590190}.; MUTAGEN 61 63 DPR->NRI: No effect on heterophilic cell adhesion. {ECO:0000269|PubMed:11590190}.; MUTAGEN 66 66 N->S: Inhibits heterophilic cell adhesion. {ECO:0000269|PubMed:11590190}.; MUTAGEN 72 75 TVDA->RVDG: No effect on heterophilic cell adhesion. {ECO:0000269|PubMed:11590190}.; MUTAGEN 78 78 R->A: Does not affect the monomeric structure. Loss of heterodimerization with CEACAM6. {ECO:0000269|PubMed:26483485}.; MUTAGEN 78 78 R->Q: Inhibits heterophilic cell adhesion. {ECO:0000269|PubMed:11590190}.; MUTAGEN 85 89 SNQQI->GTQQA: No effect on heterophilic cell adhesion. {ECO:0000269|PubMed:11590190}.; MUTAGEN 97 97 N->G: No effect on heterophilic cell adhesion. {ECO:0000269|PubMed:11590190}.; MUTAGEN 123 123 Q->A: Does not affect the monomeric structure. Decreases heterodimerization with CEACAM6. {ECO:0000269|PubMed:26483485}.; MUTAGEN 129 129 L->A: Does not affect the monomeric structure. Loss of heterodimerization with CEACAM6. {ECO:0000269|PubMed:26483485}.

Reagent Data

Name:

Carcinoembryonic antigen-related cell adhesion molecule 8 (CD67 antigen) (Carcinoembryonic antigen CGM6) (Non-specific cross-reacting antigen NCA-95) (CD antigen CD66b)

Class:

Subcategory:

Recombinant

Molecular Weight:

Source:

Species:

Human

Amino Acid Sequence:

Inquire

Tag:

Format:

Lyophilized

Formulation:

Sterile-filtered colorless solution

Formulation Concentration:

1mg/ml

Buffer Volume:

Standard

Buffer Solution:

PBS

pH:

7.4-7.5

Stabilizers

NaCl:

Null

Metal Chelating Agents

EDTA:

Null

Purity:

> 98%

Determined:

SDS-PAGE

Stained:

Inquire

Validated:

RP-HPLC

Sample Handling

Storage:

-20°C

Stability:

This bioreagent is stable at 4°C (short-term) and -70°C(long-term). After reconstitution, sample may be stored at 4°C for 2-7 days and below -18°C for future use.

Preparation:

Reconstitute in sterile distilled H2O to no less than 100ug/ml; dilute reconstituted stock further in other aqueous solutions if needed. Please review COA for lot-specific instructions. Final measurements should be determined by the end-user for optimal performance.