MMP-1

Recombinant ID:

3927

Request Datasheet

Gene of Interest

Gene Synonyms:

MMP1;CLG

Protein Names:

Interstitial collagenase (EC 3.4.24.7) (Fibroblast collagenase) (Matrix metalloproteinase-1) (MMP-1) [Cleaved into: 22 kDa interstitial collagenase; 27 kDa interstitial collagenase]

Accession Data

Organism:

Homo sapiens (Human)

Mass (kDa):

54007

Length (aa):

469

Sequence:

MHSFPPLLLLLFWGVVSHSFPATLETQEQDVDLVQKYLEKYYNLKNDGRQVEKRRNSGPVVEKLKQMQEFFGLKVTGKPDAETLKVMKQPRCGVPDVAQFVLTEGNPRWEQTHLTYRIENYTPDLPRADVDHAIEKAFQLWSNVTPLTFTKVSEGQADIMISFVRGDHRDNSPFDGPGGNLAHAFQPGPGIGGDAHFDEDERWTNNFREYNLHRVAAHELGHSLGLSHSTDIGALMYPSYTFSGDVQLAQDDIDGIQAIYGRSQNPVQPIGPQTPKACDSKLTFDAITTIRGEVMFFKDRFYMRTNPFYPEVELNFISVFWPQLPNGLEAAYEFADRDEVRFFKGNKYWAVQGQNVLHGYPKDIYSSFGFPRTVKHIDAALSEENTGKTYFFVANKYWRYDEYKRSMDPGYPKMIAHDFPGIGHKVDAVFMKDGFFYFFHGTRQYKFDPKTKRILTLQKANSWFNCRKN

Proteomics (Proteome ID):

Interstitial collagenase (EC 3.4.24.7) (Fibroblast collagenase) (Matrix metalloproteinase-1) (MMP-1) [Cleaved into: 22 kDa interstitial collagenase; 27 kDa interstitial collagenase]

Proteomics (Chromosome):

UP000005640

Mass Spectrometry:

N/A

Function [CC]:

Cleaves collagens of types I, II, and III at one site in the helical domain. Also cleaves collagens of types VII and X (PubMed:2557822, PubMed:2153297, PubMed:1645757). In case of HIV infection, interacts and cleaves the secreted viral Tat protein, leading to a decrease in neuronal Tat's mediated neurotoxicity (PubMed:16807369). {ECO:0000269|PubMed:1645757, ECO:0000269|PubMed:16807369, ECO:0000269|PubMed:2153297, ECO:0000269|PubMed:2557822}.

Metal Binding:

METAL 92 92 Zinc 2; in inhibited form. {ECO:0000244|PDB:1SU3, ECO:0000269|PubMed:15611040}.; METAL 124 124 Calcium 1. {ECO:0000244|PDB:1CGE, ECO:0000244|PDB:1CGF, ECO:0000244|PDB:1SU3, ECO:0000244|PDB:2CLT, ECO:0000244|PDB:2J0T, ECO:0000244|PDB:3SHI, ECO:0000244|PDB:966C, ECO:0000269|PubMed:8031754}.; METAL 158 158 Calcium 2. {ECO:0000244|PDB:1CGE, ECO:0000244|PDB:1CGF, ECO:0000244|PDB:1SU3, ECO:0000244|PDB:2CLT, ECO:0000244|PDB:2J0T, ECO:0000244|PDB:2TCL, ECO:0000244|PDB:4AUO, ECO:0000244|PDB:966C, ECO:0000269|PubMed:15611040, ECO:0000269|PubMed:7656013, ECO:0000269|PubMed:8031754}.; METAL 168 168 Zinc 1. {ECO:0000244|PDB:1AYK, ECO:0000244|PDB:1CGE, ECO:0000244|PDB:1CGF, ECO:0000244|PDB:1CGL, ECO:0000244|PDB:1HFC, ECO:0000244|PDB:1SU3, ECO:0000244|PDB:2AYK, ECO:0000244|PDB:2CLT, ECO:0000244|PDB:2J0T, ECO:0000244|PDB:2TCL, ECO:0000244|PDB:3AYK, ECO:0000244|PDB:3SHI, ECO:0000244|PDB:4AUO, ECO:0000244|PDB:4AYK, ECO:0000244|PDB:966C, ECO:0000269|PubMed:15611040, ECO:0000269|PubMed:7656013, ECO:0000269|PubMed:8031754, ECO:0000269|PubMed:8090713, ECO:0000269|PubMed:8278810, ECO:0000269|PubMed:9484219}.; METAL 170 170 Zinc 1. {ECO:0000244|PDB:1CGE, ECO:0000244|PDB:1CGF, ECO:0000244|PDB:1CGL, ECO:0000244|PDB:1HFC, ECO:0000244|PDB:1SU3, ECO:0000244|PDB:2AYK, ECO:0000244|PDB:2CLT, ECO:0000244|PDB:2J0T, ECO:0000244|PDB:2TCL, ECO:0000244|PDB:3SHI, ECO:0000244|PDB:4AUO, ECO:0000244|PDB:966C, ECO:0000269|PubMed:15611040, ECO:0000269|PubMed:7656013, ECO:0000269|PubMed:8031754, ECO:0000269|PubMed:8090713, ECO:0000269|PubMed:8278810, ECO:0000269|PubMed:9484219}.; METAL 175 175 Calcium 3. {ECO:0000244|PDB:1CGE, ECO:0000244|PDB:1CGF, ECO:0000244|PDB:1CGL, ECO:0000244|PDB:1HFC, ECO:0000244|PDB:1SU3, ECO:0000244|PDB:2CLT, ECO:0000244|PDB:2J0T, ECO:0000244|PDB:2TCL, ECO:0000244|PDB:3SHI, ECO:0000244|PDB:4AUO, ECO:0000244|PDB:966C, ECO:0000269|PubMed:15611040, ECO:0000269|PubMed:7656013, ECO:0000269|PubMed:8031754, ECO:0000269|PubMed:8090713, ECO:0000269|PubMed:8278810}.; METAL 176 176 Calcium 3; via carbonyl oxygen. {ECO:0000244|PDB:1AYK, ECO:0000244|PDB:1CGE, ECO:0000244|PDB:1CGF, ECO:0000244|PDB:1CGL, ECO:0000244|PDB:1HFC, ECO:0000244|PDB:1SU3, ECO:0000244|PDB:2AYK, ECO:0000244|PDB:2CLT, ECO:0000244|PDB:2J0T, ECO:0000244|PDB:2TCL, ECO:0000244|PDB:3SHI, ECO:0000244|PDB:4AUO, ECO:0000244|PDB:4AYK, ECO:0000244|PDB:966C, ECO:0000269|PubMed:15611040, ECO:0000269|PubMed:7656013, ECO:0000269|PubMed:8031754, ECO:0000269|PubMed:8090713, ECO:0000269|PubMed:8278810, ECO:0000269|PubMed:9484219}.; METAL 178 178 Calcium 3; via carbonyl oxygen. {ECO:0000244|PDB:1AYK, ECO:0000244|PDB:1CGE, ECO:0000244|PDB:1CGF, ECO:0000244|PDB:1CGL, ECO:0000244|PDB:1HFC, ECO:0000244|PDB:1SU3, ECO:0000244|PDB:2AYK, ECO:0000244|PDB:2CLT, ECO:0000244|PDB:2J0T, ECO:0000244|PDB:2TCL, ECO:0000244|PDB:3SHI, ECO:0000244|PDB:4AUO, ECO:0000244|PDB:966C, ECO:0000269|PubMed:15611040, ECO:0000269|PubMed:7656013, ECO:0000269|PubMed:8031754, ECO:0000269|PubMed:8090713, ECO:0000269|PubMed:8278810, ECO:0000269|PubMed:9484219}.; METAL 180 180 Calcium 3; via carbonyl oxygen. {ECO:0000244|PDB:1AYK, ECO:0000244|PDB:1CGE, ECO:0000244|PDB:1CGF, ECO:0000244|PDB:1CGL, ECO:0000244|PDB:1HFC, ECO:0000244|PDB:1SU3, ECO:0000244|PDB:2AYK, ECO:0000244|PDB:2CLT, ECO:0000244|PDB:2J0T, ECO:0000244|PDB:2TCL, ECO:0000244|PDB:3SHI, ECO:0000244|PDB:4AUO, ECO:0000244|PDB:966C, ECO:0000269|PubMed:15611040, ECO:0000269|PubMed:7656013, ECO:0000269|PubMed:8031754, ECO:0000269|PubMed:8090713, ECO:0000269|PubMed:8278810, ECO:0000269|PubMed:9484219}.; METAL 183 183 Zinc 1. {ECO:0000244|PDB:1AYK, ECO:0000244|PDB:1CGE, ECO:0000244|PDB:1CGF, ECO:0000244|PDB:1CGL, ECO:0000244|PDB:1HFC, ECO:0000244|PDB:1SU3, ECO:0000244|PDB:2AYK, ECO:0000244|PDB:2CLT, ECO:0000244|PDB:2J0T, ECO:0000244|PDB:2TCL, ECO:0000244|PDB:3AYK, ECO:0000244|PDB:3SHI, ECO:0000244|PDB:4AUO, ECO:0000244|PDB:4AYK, ECO:0000244|PDB:966C, ECO:0000269|PubMed:15611040, ECO:0000269|PubMed:7656013, ECO:0000269|PubMed:8031754, ECO:0000269|PubMed:8090713, ECO:0000269|PubMed:8278810, ECO:0000269|PubMed:9484219}.; METAL 190 190 Calcium 2; via carbonyl oxygen. {ECO:0000244|PDB:1CGE, ECO:0000244|PDB:1CGF, ECO:0000244|PDB:1SU3, ECO:0000244|PDB:2CLT, ECO:0000244|PDB:2J0T, ECO:0000244|PDB:2TCL, ECO:0000244|PDB:4AUO, ECO:0000244|PDB:966C, ECO:0000269|PubMed:15611040, ECO:0000269|PubMed:7656013, ECO:0000269|PubMed:8031754}.; METAL 192 192 Calcium 2; via carbonyl oxygen. {ECO:0000244|PDB:1CGE, ECO:0000244|PDB:1CGF, ECO:0000244|PDB:2CLT, ECO:0000244|PDB:2J0T, ECO:0000244|PDB:2TCL, ECO:0000244|PDB:4AUO, ECO:0000244|PDB:966C, ECO:0000269|PubMed:7656013, ECO:0000269|PubMed:8031754}.; METAL 194 194 Calcium 2. {ECO:0000244|PDB:1CGE, ECO:0000244|PDB:1CGF, ECO:0000244|PDB:1SU3, ECO:0000244|PDB:2CLT, ECO:0000244|PDB:2J0T, ECO:0000244|PDB:2TCL, ECO:0000244|PDB:4AUO, ECO:0000244|PDB:966C, ECO:0000269|PubMed:15611040, ECO:0000269|PubMed:7656013, ECO:0000269|PubMed:8031754}.; METAL 196 196 Zinc 1. {ECO:0000244|PDB:1AYK, ECO:0000244|PDB:1CGE, ECO:0000244|PDB:1CGF, ECO:0000244|PDB:1CGL, ECO:0000244|PDB:1HFC, ECO:0000244|PDB:1SU3, ECO:0000244|PDB:2AYK, ECO:0000244|PDB:2CLT, ECO:0000244|PDB:2J0T, ECO:0000244|PDB:2TCL, ECO:0000244|PDB:3AYK, ECO:0000244|PDB:3SHI, ECO:0000244|PDB:4AUO, ECO:0000244|PDB:4AYK, ECO:0000244|PDB:966C, ECO:0000269|PubMed:15611040, ECO:0000269|PubMed:7656013, ECO:0000269|PubMed:8031754, ECO:0000269|PubMed:8090713, ECO:0000269|PubMed:8278810, ECO:0000269|PubMed:9484219}.; METAL 198 198 Calcium 3. {ECO:0000244|PDB:1CGE, ECO:0000244|PDB:1CGF, ECO:0000244|PDB:1CGL, ECO:0000244|PDB:1HFC, ECO:0000244|PDB:1SU3, ECO:0000244|PDB:2CLT, ECO:0000244|PDB:2J0T, ECO:0000244|PDB:2TCL, ECO:0000244|PDB:3AYK, ECO:0000244|PDB:3SHI, ECO:0000244|PDB:4AUO, ECO:0000244|PDB:4AYK, ECO:0000244|PDB:966C, ECO:0000269|PubMed:15611040, ECO:0000269|PubMed:7656013, ECO:0000269|PubMed:8031754, ECO:0000269|PubMed:8090713, ECO:0000269|PubMed:8278810}.; METAL 199 199 Calcium 1. {ECO:0000244|PDB:1CGE, ECO:0000244|PDB:1CGF, ECO:0000244|PDB:1SU3, ECO:0000244|PDB:2CLT, ECO:0000244|PDB:2J0T, ECO:0000244|PDB:3SHI, ECO:0000244|PDB:4AUO, ECO:0000244|PDB:966C, ECO:0000269|PubMed:15611040, ECO:0000269|PubMed:8031754}.; METAL 201 201 Calcium 3. {ECO:0000244|PDB:1AYK, ECO:0000244|PDB:1CGE, ECO:0000244|PDB:1CGF, ECO:0000244|PDB:1CGL, ECO:0000244|PDB:1HFC, ECO:0000244|PDB:1SU3, ECO:0000244|PDB:2AYK, ECO:0000244|PDB:2CLT, ECO:0000244|PDB:2J0T, ECO:0000244|PDB:2TCL, ECO:0000244|PDB:3AYK, ECO:0000244|PDB:3SHI, ECO:0000244|PDB:4AUO, ECO:0000244|PDB:966C, ECO:0000269|PubMed:15611040, ECO:0000269|PubMed:7656013, ECO:0000269|PubMed:8031754, ECO:0000269|PubMed:8090713, ECO:0000269|PubMed:8278810, ECO:0000269|PubMed:9484219}.; METAL 218 218 Zinc 2; catalytic. {ECO:0000244|PDB:1AYK, ECO:0000244|PDB:1CGE, ECO:0000244|PDB:1CGF, ECO:0000244|PDB:1CGL, ECO:0000244|PDB:1HFC, ECO:0000244|PDB:1SU3, ECO:0000244|PDB:2AYK, ECO:0000244|PDB:2CLT, ECO:0000244|PDB:2J0T, ECO:0000244|PDB:2TCL, ECO:0000244|PDB:3AYK, ECO:0000244|PDB:3SHI, ECO:0000244|PDB:4AUO, ECO:0000244|PDB:4AYK, ECO:0000244|PDB:966C, ECO:0000269|PubMed:15611040, ECO:0000269|PubMed:7656013, ECO:0000269|PubMed:8031754, ECO:0000269|PubMed:8090713, ECO:0000269|PubMed:8278810, ECO:0000269|PubMed:9484219}.; METAL 222 222 Zinc 2; catalytic. {ECO:0000244|PDB:1AYK, ECO:0000244|PDB:1CGE, ECO:0000244|PDB:1CGF, ECO:0000244|PDB:1CGL, ECO:0000244|PDB:1HFC, ECO:0000244|PDB:1SU3, ECO:0000244|PDB:2AYK, ECO:0000244|PDB:2CLT, ECO:0000244|PDB:2J0T, ECO:0000244|PDB:2TCL, ECO:0000244|PDB:3AYK, ECO:0000244|PDB:3SHI, ECO:0000244|PDB:4AUO, ECO:0000244|PDB:4AYK, ECO:0000244|PDB:966C, ECO:0000269|PubMed:15611040, ECO:0000269|PubMed:7656013, ECO:0000269|PubMed:8031754, ECO:0000269|PubMed:8090713, ECO:0000269|PubMed:8278810, ECO:0000269|PubMed:9484219}.; METAL 228 228 Zinc 2; catalytic. {ECO:0000244|PDB:1AYK, ECO:0000244|PDB:1CGE, ECO:0000244|PDB:1CGF, ECO:0000244|PDB:1CGL, ECO:0000244|PDB:1HFC, ECO:0000244|PDB:1SU3, ECO:0000244|PDB:2AYK, ECO:0000244|PDB:2CLT, ECO:0000244|PDB:2J0T, ECO:0000244|PDB:2TCL, ECO:0000244|PDB:3AYK, ECO:0000244|PDB:3SHI, ECO:0000244|PDB:4AUO, ECO:0000244|PDB:4AYK, ECO:0000244|PDB:966C, ECO:0000269|PubMed:15611040, ECO:0000269|PubMed:7656013, ECO:0000269|PubMed:8031754, ECO:0000269|PubMed:8090713, ECO:0000269|PubMed:8278810, ECO:0000269|PubMed:9484219}.; METAL 285 285 Calcium 4; via carbonyl oxygen. {ECO:0000244|PDB:1SU3, ECO:0000244|PDB:2CLT, ECO:0000244|PDB:4AUO, ECO:0000269|PubMed:15611040}.; METAL 329 329 Calcium 4; via carbonyl oxygen. {ECO:0000244|PDB:1SU3, ECO:0000244|PDB:2CLT, ECO:0000244|PDB:4AUO, ECO:0000269|PubMed:15611040}.; METAL 378 378 Calcium 4; via carbonyl oxygen. {ECO:0000244|PDB:1SU3, ECO:0000244|PDB:2CLT, ECO:0000244|PDB:4AUO, ECO:0000269|PubMed:15611040}.; METAL 427 427 Calcium 4; via carbonyl oxygen. {ECO:0000244|PDB:1SU3, ECO:0000244|PDB:2CLT, ECO:0000244|PDB:4AUO, ECO:0000269|PubMed:15611040}.

Site:

SITE 143 143 Not glycosylated. {ECO:0000269|PubMed:10092871}.; SITE 269 270 Cleavage; by autolysis. {ECO:0000269|PubMed:2557822}.

Tissue Specificity:

N/A

Disease:

N/A

Mutagenesis:

MUTAGEN 360 360 Y->F: Partial reduction of tyrosine phosphorylation in the presence of PKDCC/VLK. {ECO:0000269|PubMed:25171405}.

Reagent Data

Name:

Interstitial collagenase (EC 3.4.24.7) (Fibroblast collagenase) (Matrix metalloproteinase-1) (MMP-1) [Cleaved into: 22 kDa interstitial collagenase; 27 kDa interstitial collagenase]

Class:

Subcategory:

Recombinant

Molecular Weight:

Source:

Species:

Human

Amino Acid Sequence:

Inquire

Tag:

Format:

Lyophilized

Formulation:

Sterile-filtered colorless solution

Formulation Concentration:

1mg/ml

Buffer Volume:

Standard

Buffer Solution:

PBS

pH:

7.4-7.5

Stabilizers

NaCl:

Null

Metal Chelating Agents

EDTA:

Null

Purity:

> 98%

Determined:

SDS-PAGE

Stained:

Inquire

Validated:

RP-HPLC

Sample Handling

Storage:

-20°C

Stability:

This bioreagent is stable at 4°C (short-term) and -70°C(long-term). After reconstitution, sample may be stored at 4°C for 2-7 days and below -18°C for future use.

Preparation:

Reconstitute in sterile distilled H2O to no less than 100ug/ml; dilute reconstituted stock further in other aqueous solutions if needed. Please review COA for lot-specific instructions. Final measurements should be determined by the end-user for optimal performance.