IL-6 R alpha

Gene Synonyms:

Protein Names:

Organism:

Homo sapiens (Human)

Mass (kDa):

51548

Length (aa):

468

Sequence:

MLAVGCALLAALLAAPGAALAPRRCPAQEVARGVLTSLPGDSVTLTCPGVEPEDNATVHWVLRKPAAGSHPSRWAGMGRRLLLRSVQLHDSGNYSCYRAGRPAGTVHLLVDVPPEEPQLSCFRKSPLSNVVCEWGPRSTPSLTTKAVLLVRKFQNSPAEDFQEPCQYSQESQKFSCQLAVPEGDSSFYIVSMCVASSVGSKFSKTQTFQGCGILQPDPPANITVTAVARNPRWLSVTWQDPHSWNSSFYRLRFELRYRAERSKTFTTWMVKDLQHHCVIHDAWSGLRHVVQLRAQEEFGQGEWSEWSPEAMGTPWTESRSPPAENEVSTPMQALTTNKDDDNILFRDSANATSLPVQDSSSVPLPTFLVAGGSLAFGTLLCIAIVLRFKKTWKLRALKEGKTSMHPPYSLGQLVPERPRPTPVLVPLISPPVSPSSLGSDNTSSHNRPDARDPRSPYDISNTDYFFPR

Proteomics (Proteome ID):

Interleukin-6 receptor subunit alpha (IL-6 receptor subunit alpha) (IL-6R subunit alpha) (IL-6R-alpha) (IL-6RA) (IL-6R 1) (Membrane glycoprotein 80) (gp80) (CD antigen CD126)

Proteomics (Chromosome):

UP000005640

Mass Spectrometry:

N/A

Function [CC]:

Part of the receptor for interleukin 6. Binds to IL6 with low affinity, but does not transduce a signal. Signal activation necessitate an association with IL6ST. Activation may lead to the regulation of the immune response, acute-phase reactions and hematopoiesis.; Low concentration of a soluble form of IL6 receptor acts as an agonist of IL6 activity.

Metal Binding:

N/A

Site:

SITE 245 245 Not glycosylated. {ECO:0000269|PubMed:10066782}.

Tissue Specificity:

Isoform 2 is expressed in peripheral blood mononuclear cells and weakly found in urine and serum.

Disease:

N/A

Mutagenesis:

MUTAGEN 121 121 C->S: Complete loss of ligand-binding. {ECO:0000269|PubMed:8467812}.; MUTAGEN 122 122 F->A: No change of ligand-binding and IL6 signaling. {ECO:0000269|PubMed:8467812}.; MUTAGEN 132 132 C->A: Complete loss of ligand-binding. {ECO:0000269|PubMed:8467812}.; MUTAGEN 134 134 W->L: Complete loss of ligand-binding. {ECO:0000269|PubMed:8467812}.; MUTAGEN 140 140 P->G: No change of ligand-binding and IL6 signaling. {ECO:0000269|PubMed:8467812}.; MUTAGEN 153 153 F->L: No change of ligand-binding and IL6 signaling. {ECO:0000269|PubMed:8467812}.; MUTAGEN 165 165 C->L: Complete loss of ligand-binding. {ECO:0000269|PubMed:8467812}.; MUTAGEN 174 174 F->L: No change of ligand-binding and IL6 signaling. {ECO:0000269|PubMed:8467812}.; MUTAGEN 176 176 C->A: Complete loss of ligand-binding. {ECO:0000269|PubMed:8467812}.; MUTAGEN 184 184 D->T: 30% decrease of ligand-binding and IL6 signaling. {ECO:0000269|PubMed:8467812}.; MUTAGEN 190 190 V->G: 80% decrease of ligand-binding and no IL6 signaling. {ECO:0000269|PubMed:8467812}.; MUTAGEN 193 193 C->D: Complete loss of ligand-binding. {ECO:0000269|PubMed:8467812}.; MUTAGEN 211 211 C->A: No change of ligand-binding and IL6 signaling. {ECO:0000269|PubMed:8467812}.; MUTAGEN 217 217 D->V: Complete loss of ligand-binding. {ECO:0000269|PubMed:8467812}.; MUTAGEN 232 232 R->S: 30% decrease of ligand-binding and IL6 signaling. {ECO:0000269|PubMed:8467812}.; MUTAGEN 233 233 W->Q: 30% decrease of ligand-binding and increase of IL6 signaling. {ECO:0000269|PubMed:8467812}.; MUTAGEN 254 254 E->A: 50% decrease of ligand-binding and IL6 signaling. {ECO:0000269|PubMed:8467812}.; MUTAGEN 277 277 C->D: 30% increase of ligand-binding and 100% increase in IL6 signaling. {ECO:0000269|PubMed:8467812}.; MUTAGEN 278 278 V->N: 50% Decrease of ligand-binding and 50% increase in IL6 signaling. {ECO:0000269|PubMed:8467812}.; MUTAGEN 279 279 I->D: Complete loss of ligand-binding. {ECO:0000269|PubMed:8467812}.; MUTAGEN 280 280 H->I: No change of ligand-binding and no IL6 signaling. {ECO:0000269|PubMed:8467812}.; MUTAGEN 281 281 D->G: 70% decrease of ligand-binding and no IL6 signaling. {ECO:0000269|PubMed:8467812}.; MUTAGEN 285 285 G->D: 80% decrease of ligand-binding and no IL6 signaling. {ECO:0000269|PubMed:8467812}.; MUTAGEN 291 291 Q->K: Complete loss of ligand-binding. {ECO:0000269|PubMed:8467812}.; MUTAGEN 293 293 R->G: Complete loss of ligand-binding. {ECO:0000269|PubMed:8467812}.

Name:

Interleukin-6 receptor subunit alpha (IL-6 receptor subunit alpha) (IL-6R subunit alpha) (IL-6R-alpha) (IL-6RA) (IL-6R 1) (Membrane glycoprotein 80) (gp80) (CD antigen CD126)

Class:

Subcategory:

Recombinant

Source:

Species:

Human

Amino Acid Sequence:

Tag:

Format:

Lyophilized

Formulation:

Sterile-filtered colorless solution

Formulation Concentration:

1mg/ml

Buffer Volume:

Standard

Buffer Solution:

PBS

pH:

7.4-7.5

NaCl:

Null

EDTA:

Null

Purity:

> 98%

Determined:

SDS-PAGE

Stained:

Inquire

Validated:

RP-HPLC

Storage:

-20°C

Stability:

This bioreagent is stable at 4°C (short-term) and -70°C(long-term). After reconstitution, sample may be stored at 4°C for 2-7 days and below -18°C for future use.

Preparation:

Reconstitute in sterile distilled H2O to no less than 100ug/ml; dilute reconstituted stock further in other aqueous solutions if needed. Please review COA for lot-specific instructions. Final measurements should be determined by the end-user for optimal performance.