APCS

Gene Synonyms:

Protein Names:

Organism:

Homo sapiens (Human)

Mass (kDa):

25387

Length (aa):

223

Sequence:

MNKPLLWISVLTSLLEAFAHTDLSGKVFVFPRESVTDHVNLITPLEKPLQNFTLCFRAYSDLSRAYSLFSYNTQGRDNELLVYKERVGEYSLYIGRHKVTSKVIEKFPAPVHICVSWESSSGIAEFWINGTPLVKKGLRQGYFVEAQPKIVLGQEQDSYGGKFDRSQSFVGEIGDLYMWDSVLPPENILSAYQGTPLPANILDWQALNYEIRGYVIIKPLVWV

Proteomics (Proteome ID):

Serum amyloid P-component (SAP) (9.5S alpha-1-glycoprotein) [Cleaved into: Serum amyloid P-component(1-203)]

Proteomics (Chromosome):

UP000005640

Mass Spectrometry:

Mass=25462.5; Mass_error=1.1; Method=Electrospray; Range=20-223; Evidence={ECO:0000269|PubMed:15174148, ECO:0000269|PubMed:8202534}; Mass=25463; Mass_error=3; Method=MALDI; Range=20-223; Evidence={ECO:0000269|PubMed:15174148, ECO:0000269|PubMed:8202534}; Mass=1285.78; Method=MALDI; Range=213-223; Evidence={ECO:0000269|PubMed:15174148}; Mass=1186.71; Method=MALDI; Range=213-222; Evidence={ECO:0000269|PubMed:15174148};

Function [CC]:

Can interact with DNA and histones and may scavenge nuclear material released from damaged circulating cells. May also function as a calcium-dependent lectin.

Metal Binding:

METAL 77 77 Calcium 1. {ECO:0000255|PROSITE-ProRule:PRU01172}.; METAL 78 78 Calcium 1. {ECO:0000255|PROSITE-ProRule:PRU01172}.; METAL 155 155 Calcium 1. {ECO:0000255|PROSITE-ProRule:PRU01172}.; METAL 155 155 Calcium 2. {ECO:0000255|PROSITE-ProRule:PRU01172}.; METAL 156 156 Calcium 1; via carbonyl oxygen. {ECO:0000255|PROSITE-ProRule:PRU01172}.; METAL 157 157 Calcium 1. {ECO:0000255|PROSITE-ProRule:PRU01172}.; METAL 157 157 Calcium 2. {ECO:0000255|PROSITE-ProRule:PRU01172}.; METAL 167 167 Calcium 2. {ECO:0000255|PROSITE-ProRule:PRU01172}.

Site:

N/A

Tissue Specificity:

Found in serum and urine. {ECO:0000269|PubMed:15174148}.

Disease:

Note=SAP is a precursor of amyloid component P which is found in basement membrane and associated with amyloid deposits.

Mutagenesis:

N/A

Name:

Serum amyloid P-component (SAP) (9.5S alpha-1-glycoprotein) [Cleaved into: Serum amyloid P-component(1-203)]

Class:

Subcategory:

Recombinant

Source:

Species:

Human

Amino Acid Sequence:

Tag:

Format:

Lyophilized

Formulation:

Sterile-filtered colorless solution

Formulation Concentration:

1mg/ml

Buffer Volume:

Standard

Buffer Solution:

PBS

pH:

7.4-7.5

NaCl:

Null

EDTA:

Null

Purity:

> 98%

Determined:

SDS-PAGE

Stained:

Inquire

Validated:

RP-HPLC

Storage:

-20°C

Stability:

This bioreagent is stable at 4°C (short-term) and -70°C(long-term). After reconstitution, sample may be stored at 4°C for 2-7 days and below -18°C for future use.

Preparation:

Reconstitute in sterile distilled H2O to no less than 100ug/ml; dilute reconstituted stock further in other aqueous solutions if needed. Please review COA for lot-specific instructions. Final measurements should be determined by the end-user for optimal performance.