Arginase 1
Recombinant ID:
3940
Gene of Interest
Gene Synonyms:
ARG1
Protein Names:
Arginase-1 (EC 3.5.3.1) (Liver-type arginase) (Type I arginase)
Accession Data
Organism:
Homo sapiens (Human)
Mass (kDa):
34735
Length (aa):
322
Proteomics (Proteome ID):
Arginase-1 (EC 3.5.3.1) (Liver-type arginase) (Type I arginase)
Proteomics (Chromosome):
UP000005640
Sequence:
MSAKSRTIGIIGAPFSKGQPRGGVEEGPTVLRKAGLLEKLKEQECDVKDYGDLPFADIPNDSPFQIVKNPRSVGKASEQLAGKVAEVKKNGRISLVLGGDHSLAIGSISGHARVHPDLGVIWVDAHTDINTPLTTTSGNLHGQPVSFLLKELKGKIPDVPGFSWVTPCISAKDIVYIGLRDVDPGEHYILKTLGIKYFSMTEVDRLGIGKVMEETLSYLLGRKKRPIHLSFDVDGLDPSFTPATGTPVVGGLTYREGLYITEEIYKTGLLSGLDIMEVNPSLGKTPEEVTRTVNTAVAITLACFGLAREGNHKPIDYLNPPK
Analysis Summary:
Alternative sequence (2); Beta strand (11); Binding site (3); Chain (1); Helix (17); Metal binding (8); Modified residue (6); Natural variant (10); Region (2); Sequence conflict (3); Turn (3),N/A,By arginine or homoarginine.,Within the immune system initially reported to be selectively expressed in granulocytes (polymorphonuclear leukocytes [PMNs]) (PubMed:15546957). Also detected in macrophages mycobacterial granulomas (PubMed:23749634). Expressed in group2 innate lymphoid cells (ILC2s) during lung disease (PubMed:27043409). {ECO:0000269|PubMed:15546957, ECO:0000269|PubMed:23749634}.,H2O [CHEBI:15377]; urea [CHEBI:16199]; L-arginine [CHEBI:32682]; Mn(2+) [CHEBI:29035]; L-ornithine [CHEBI:46911],H2O [CHEBI:15377]; urea [CHEBI:16199]; L-arginine [CHEBI:32682]; L-ornithine [CHEBI:46911],Mn(2+) [CHEBI:29035],Argininemia (ARGIN) [MIM:207800]: A rare autosomal recessive disorder of the urea cycle. Arginine is elevated in the blood and cerebrospinal fluid, and periodic hyperammonemia occurs. Clinical manifestations include developmental delay, seizures, mental retardation, hypotonia, ataxia and progressive spastic quadriplegia. {ECO:0000269|PubMed:1463019, ECO:0000269|PubMed:22959135, ECO:0000269|PubMed:23859858, ECO:0000269|PubMed:7649538}. Note=The disease is caused by mutations affecting the gene represented in this entry.
Reagent Data
Name:
Arginase-1 (EC 3.5.3.1) (Liver-type arginase) (Type I arginase)
Subcategory:
Recombinant
Molecular Weight:
35.6 kDa
Source:
HEK293
Species:
Human
Tag:
Format:
Lyophilized
pH:
7.4-7.5
Formulation:
Sterile-filtered colorless solution
Formulation Concentration:
1mg/ml
Buffer Volume:
Standard
Buffer Solution:
PBS
Metal Chelating Agents
Purity:
> 98%
Determined:
SDS-PAGE
Validated:
RP-HPLC
Sample Handling
Storage:
-20°C
Stability:
This bioreagent is stable at 4°C (short-term) and -70°C(long-term). After reconstitution, sample may be stored at 4°C for 2-7 days and below -18°C for future use.
Preparation:
Reconstitute in sterile distilled H2O to no less than 100ug/ml; dilute reconstituted stock further in other aqueous solutions if needed. Please review COA for lot-specific instructions. Final measurements should be determined by the end-user for optimal performance.
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