ROR1
Recombinant ID:
3534
Gene of Interest
Gene Synonyms:
Ror1;Ntrkr1
Protein Names:
Inactive tyrosine-protein kinase transmembrane receptor ROR1 (mROR1) (Neurotrophic tyrosine kinase, receptor-related 1)
Accession Data
Organism:
Mus musculus (Mouse)
Mass (kDa):
104088
Length (aa):
937
Metal Binding:
Pending Verification
Proteomics (Proteome ID):
Inactive tyrosine-protein kinase transmembrane receptor ROR1 (mROR1) (Neurotrophic tyrosine kinase, receptor-related 1)
Proteomics (Chromosome):
UP000000589
Disease:
N/A
Mutagenesis:
N/A
Sequence:
MHRPRRRGTRPPPLALLAALLLAARGADAQETELSVSAELVPTSSWNTSSEIDKGSYLTLDEPMNNITTSLGQTAELHCKVSGNPPPSIRWFKNDAPVVQEPRRISFRATNYGSRLRIRNLDTTDTGYFQCVATNGKKVVSTTGVLFVKFGPPPTASPGSSDEYEEDGFCQPYRGIACARFIGNRTVYMESLHMQGEIENQITAAFTMIGTSSHLSDKCSQFAIPSLCHYAFPYCDETSSVPKPRDLCRDECEVLENVLCQTEYIFARSNPMILMRLKLPNCEDLPQPESPEAANCIRIGIPMADPINKNHKCYNSTGVDYRGTVSVTKSGRQCQPWNSQYPHTHSFTALRFPELNGGHSYCRNPGNQKEAPWCFTLDENFKSDLCDIPACDSKDSKEKNKMEILYILVPSVAIPLAIAFLFFFICVCRNNQKSSSPPVQRQPKPVRGQNVEMSMLNAYKPKSKAKELPLSAVRFMEELGECTFGKIYKGHLYLPGMDHAQLVAIKTLKDYNNPQQWTEFQQEASLMAELHHPNIVCLLGAVTQEQPVCMLFEYMNQGDLHEFLIMRSPHSDVGCSSDEDGTVKSSLDHGDFLHIAIQIAAGMEYLSSHFFVHKDLAARNILIGEQLHVKISDLGLSREIYSADYYRVQSKSSLPIRWMPPEAIMYGKFSSDSDIWSFGVVLWEIFSFGLQPYYGFSNQEVIEMVRKRQLLPCSEDCPPRMYSLMTECWNEIPSRRPRFKDIHVRLRSWEGLSSHTSSTTPSGGNATTQTTSLSASPVSNLSNPRFPNYMFPSQGITPQGQIAGFIGPAIPQNQRFIPINGYPIPPGYAAFPAAHYQPAGPPRVIQHCPPPKSRSPSSASGSTSTGHVASLPSSGSNQEANVPLLPHMSIPNHPGGMGITVFGNKSQKPYKIDSKQSSLLGDSHIHGHTESMISAEV
Function [CC]:
Has very low kinase activity in vitro and is unlikely to function as a tyrosine kinase in vivo (By similarity). Receptor for ligand WNT5A which activate downstream NFkB signaling pathway and may result in the inhibition of WNT3A-mediated signaling (By similarity). In inner ear, crucial for spiral ganglion neurons to innervate auditory hair cells (PubMed:27162350). {ECO:0000250|UniProtKB:Q01973, ECO:0000269|PubMed:27162350}.
Analysis Summary:
Binding site (1); Chain (1); Compositional bias (3); Disulfide bond (9); Domain (4); Glycosylation (4); Modified residue (1); Nucleotide binding (1); Sequence conflict (1); Signal peptide (1); Topological domain (2); Transmembrane (1); At postnatal P0, expressed in heart, lung, liver, kidney, spleen and inner ear (PubMed:27162350). In the inner ear, at 14.5 dpc, detected in spiral ganglia, the cochlear epithelium and the vesitbule. At 17.5 dpc, expression increases in spiral ganglion neurons axon terminals adjacent to auditory hair cells. In the differentiating cochlear epithelium, the expression is intense in the stria vascularis. By P0, expression in the stria vascularis is weakened (PubMed:27162350). {ECO:0000269|PubMed:27162350}.; At postnatal P0, expressed in heart, lung, liver, kidney, spleen and inner ear. {ECO:0000269|PubMed:27162350}.
Reagent Data
Name:
Inactive tyrosine-protein kinase transmembrane receptor ROR1 (mROR1) (Neurotrophic tyrosine kinase, receptor-related 1)
Subcategory:
Recombinant
Source:
HEK293
Species:
Format:
Lyophilized
pH:
7.4-7.5
Formulation:
Sterile-filtered colorless solution
Formulation Concentration:
1mg/ml
Buffer Volume:
Standard
Buffer Solution:
PBS
Metal Chelating Agents
Determined:
SDS-PAGE
Purity:
> 98%
Validated:
RP-HPLC
Sample Handling
Storage:
-20°C
Stability:
This bioreagent is stable at 4°C (short-term) and -70°C(long-term). After reconstitution, sample may be stored at 4°C for 2-7 days and below -18°C for future use.
Preparation:
Reconstitute in sterile distilled H2O to no less than 100ug/ml; dilute reconstituted stock further in other aqueous solutions if needed. Please review COA for lot-specific instructions. Final measurements should be determined by the end-user for optimal performance.
Request a Datasheet
We'll respond with your requested information within a day!
