CD99
Recombinant ID:
3271
Gene of Interest
Gene Synonyms:
CD99;MIC2;MIC2X;MIC2Y
Protein Names:
CD99 antigen (12E7) (E2 antigen) (Protein MIC2) (T-cell surface glycoprotein E2) (CD antigen CD99)
Accession Data
Organism:
Homo sapiens (Human)
Mass (kDa):
18848
Length (aa):
185
Metal Binding:
Pending Verification
Proteomics (Proteome ID):
CD99 antigen (12E7) (E2 antigen) (Protein MIC2) (T-cell surface glycoprotein E2) (CD antigen CD99)
Proteomics (Chromosome):
UP000005640
Disease:
N/A
Mutagenesis:
N/A
Sequence:
MARGAALALLLFGLLGVLVAAPDGGFDLSDALPDNENKKPTAIPKKPSAGDDFDLGDAVVDGENDDPRPPNPPKPMPNPNPNHPSSSGSFSDADLADGVSGGEGKGGSDGGGSHRKEGEEADAPGVIPGIVGAVVVAVAGAISSFIAYQKKKLCFKENAEQGEVDMESHRNANAEPAVQRTLLEK
Function [CC]:
Involved in T-cell adhesion processes and in spontaneous rosette formation with erythrocytes. Plays a role in a late step of leukocyte extravasation helping leukocytes to overcome the endothelial basement membrane. Acts at the same site as, but independently of, PECAM1. Involved in T-cell adhesion processes (By similarity). {ECO:0000250}.
Analysis Summary:
Alternative sequence (19); Beta strand (4); Chain (3); Domain (1); Erroneous initiation (2); Glycosylation (9); Helix (3); Lipidation (2); Modified residue (7); Motif (3); Mutagenesis (21); Natural variant (2); Region (4); Repeat (48); Sequence conflict (10); Signal peptide (1); Site (1); Topological domain (2); Transmembrane (1); Turn (2); The name KL-6 was originally that of a murine monoclonal antibody reacting with pulmonary adenocarcinoma cell lines and pulmonary epithelial cells. This antibody recognizes a sialylated carbohydrate chain on MUC1.; During fetal development, expressed at low levels in the colonic epithelium from 13 weeks of gestation. {ECO:0000269|PubMed:9536947}.; Expressed on the apical surface of epithelial cells, especially of airway passages, breast and uterus. Also expressed in activated and unactivated T-cells. Overexpressed in epithelial tumors, such as breast or ovarian cancer and also in non-epithelial tumor cells. Isoform Y is expressed in tumor cells only. {ECO:0000269|PubMed:15513966, ECO:0000269|PubMed:9212228}.
Reagent Data
Name:
CD99 antigen (12E7) (E2 antigen) (Protein MIC2) (T-cell surface glycoprotein E2) (CD antigen CD99)
Subcategory:
Recombinant
Source:
HEK293
Species:
Format:
Lyophilized
pH:
7.4-7.5
Formulation:
Sterile-filtered colorless solution
Formulation Concentration:
1mg/ml
Buffer Volume:
Standard
Buffer Solution:
PBS
Metal Chelating Agents
Determined:
SDS-PAGE
Purity:
> 98%
Validated:
RP-HPLC
Sample Handling
Storage:
-20°C
Stability:
This bioreagent is stable at 4°C (short-term) and -70°C(long-term). After reconstitution, sample may be stored at 4°C for 2-7 days and below -18°C for future use.
Preparation:
Reconstitute in sterile distilled H2O to no less than 100ug/ml; dilute reconstituted stock further in other aqueous solutions if needed. Please review COA for lot-specific instructions. Final measurements should be determined by the end-user for optimal performance.
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