IL-18BP
Recombinant ID:
3412
Gene of Interest
Gene Synonyms:
IL18BP
Protein Names:
Interleukin-18-binding protein (IL-18BP) (Tadekinig-alfa)
Accession Data
Organism:
Homo sapiens (Human)
Mass (kDa):
21099
Length (aa):
194
Metal Binding:
Pending Verification
Proteomics (Proteome ID):
Interleukin-18-binding protein (IL-18BP) (Tadekinig-alfa)
Proteomics (Chromosome):
UP000005640
Disease:
N/A
Mutagenesis:
N/A
Sequence:
MTMRHNWTPDLSPLWVLLLCAHVVTLLVRATPVSQTTTAATASVRSTKDPCPSQPPVFPAAKQCPALEVTWPEVEVPLNGTLSLSCVACSRFPNFSILYWLGNGSFIEHLPGRLWEGSTSRERGSTGTQLCKALVLEQLTPALHSTNFSCVLVDPEQVVQRHVVLAQLWAGLRATLPPTQEALPSSHSSPQQQG
Function [CC]:
Isoform A binds to IL-18 and inhibits its activity. Functions as an inhibitor of the early TH1 cytokine response. {ECO:0000269|PubMed:10023777, ECO:0000269|PubMed:10655506}.
Analysis Summary:
Alternative sequence (4); Chain (1); Disulfide bond (1); Domain (1); Erroneous initiation (5); Glycosylation (5); Natural variant (2); Sequence caution (2); Signal peptide (1); Strongly expressed in heart, lung, placenta and spleen. {ECO:0000269|PubMed:10023777, ECO:0000269|PubMed:10094485}.
Reagent Data
Name:
Interleukin-18-binding protein (IL-18BP) (Tadekinig-alfa)
Subcategory:
Recombinant
Source:
HEK293
Species:
Format:
Lyophilized
pH:
7.4-7.5
Formulation:
Sterile-filtered colorless solution
Formulation Concentration:
1mg/ml
Buffer Volume:
Standard
Buffer Solution:
PBS
Metal Chelating Agents
Determined:
SDS-PAGE
Purity:
> 98%
Validated:
RP-HPLC
Sample Handling
Storage:
-20°C
Stability:
This bioreagent is stable at 4°C (short-term) and -70°C(long-term). After reconstitution, sample may be stored at 4°C for 2-7 days and below -18°C for future use.
Preparation:
Reconstitute in sterile distilled H2O to no less than 100ug/ml; dilute reconstituted stock further in other aqueous solutions if needed. Please review COA for lot-specific instructions. Final measurements should be determined by the end-user for optimal performance.
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