CD2
Recombinant ID:
3221
Gene of Interest
Gene Synonyms:
CD2;SRBC
Protein Names:
T-cell surface antigen CD2 (Erythrocyte receptor) (LFA-2) (LFA-3 receptor) (Rosette receptor) (T-cell surface antigen T11/Leu-5) (CD antigen CD2)
Accession Data
Organism:
Homo sapiens (Human)
Mass (kDa):
39448
Length (aa):
351
Metal Binding:
Pending Verification
Proteomics (Proteome ID):
T-cell surface antigen CD2 (Erythrocyte receptor) (LFA-2) (LFA-3 receptor) (Rosette receptor) (T-cell surface antigen T11/Leu-5) (CD antigen CD2)
Proteomics (Chromosome):
UP000005640
Disease:
N/A
Mutagenesis:
MUTAGEN 67 67 K->R: Loss of CD58 binding. {ECO:0000269|PubMed:2444890}.; MUTAGEN 70 70 Q->K: Loss of CD58 binding. {ECO:0000269|PubMed:2444890}.; MUTAGEN 110 110 Y->D: Loss of CD58 and CD59 binding. {ECO:0000269|PubMed:2444890}.; MUTAGEN 111 111 D->H: Loss of CD58 and CD59 binding. {ECO:0000269|PubMed:2444890}.
Sequence:
MSFPCKFVASFLLIFNVSSKGAVSKEITNALETWGALGQDINLDIPSFQMSDDIDDIKWEKTSDKKKIAQFRKEKETFKEKDTYKLFKNGTLKIKHLKTDDQDIYKVSIYDTKGKNVLEKIFDLKIQERVSKPKISWTCINTTLTCEVMNGTDPELNLYQDGKHLKLSQRVITHKWTTSLSAKFKCTAGNKVSKESSVEPVSCPEKGLDIYLIIGICGGGSLLMVFVALLVFYITKRKKQRSRRNDEELETRAHRVATEERGRKPHQIPASTPQNPATSQHPPPPPGHRSQAPSHRPPPPGHRVQHQPQKRPPAPSGTQVHQQKGPPLPRPRVQPKPPHGAAENSLSPSSN
Function [CC]:
CD2 interacts with lymphocyte function-associated antigen CD58 (LFA-3) and CD48/BCM1 to mediate adhesion between T-cells and other cell types. CD2 is implicated in the triggering of T-cells, the cytoplasmic domain is implicated in the signaling function.
Analysis Summary:
Beta strand (16); Chain (1); Compositional bias (1); Disulfide bond (2); Domain (2); Glycosylation (3); Helix (3); Mutagenesis (4); Natural variant (3); Region (2); Sequence conflict (2); Signal peptide (1); Topological domain (2); Transmembrane (1); Turn (2)
Reagent Data
Name:
T-cell surface antigen CD2 (Erythrocyte receptor) (LFA-2) (LFA-3 receptor) (Rosette receptor) (T-cell surface antigen T11/Leu-5) (CD antigen CD2)
Subcategory:
Recombinant
Source:
HEK293
Species:
Format:
Lyophilized
pH:
7.4-7.5
Formulation:
Sterile-filtered colorless solution
Formulation Concentration:
1mg/ml
Buffer Volume:
Standard
Buffer Solution:
PBS
Metal Chelating Agents
Determined:
SDS-PAGE
Purity:
> 98%
Validated:
RP-HPLC
Sample Handling
Storage:
-20°C
Stability:
This bioreagent is stable at 4°C (short-term) and -70°C(long-term). After reconstitution, sample may be stored at 4°C for 2-7 days and below -18°C for future use.
Preparation:
Reconstitute in sterile distilled H2O to no less than 100ug/ml; dilute reconstituted stock further in other aqueous solutions if needed. Please review COA for lot-specific instructions. Final measurements should be determined by the end-user for optimal performance.
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