Often referred to as the building blocks of DNA & RNA, a nucleoside is essentially a ribose or deoxyribose sugar carrying a base (adenine, guanine, thymine, cytosine, or uracil) at it’s 1’ position. This complex plays a defining role in the production of quality oligonucleotide sequences. Synthetic versions of nucleosides called amidites are chemical compounds are available in various structures to support principals in sold phase synthesis-such as 5’ protection, directional confirmation, and coupling consistency. With the addition of an open phosphate group at the 3’, phosphoramidites introduce the most complete synthetic compound to simply plug into a custom synthesis design. 



See the full list of in-house Amidites used in our synthesis below:



Nucleosides

Unprotected mononucleosides

I-Unprotected deoxy mononucleosides
A: Deoxy Nucleosides
2'-β-D-Deoxyadenosine Monohydrate
2'-β-D-Deoxycytidine (Free Base)
2'-β-D-Deoxycytidine Monohydrate
2'-β-D-Deoxyguanosine Monohydrate
2'-β-D-Deoxyinosine
2'-β-D-Deoxyuridine
Thymidine Monohydrate
B: Dideoxy nucleosides
2',3'-β-D-Dideoxyadenosine
2',3'-β-D-Dideoxycytidine
2',3'-β-D-Dideoxyguanosine
2',3'-β-D-Dideoxyinosine
2',3'-β-D-Dideoxyuridine
3'-β-D-Deoxythymidine
C: Alpha deoxy nucleosides
Alpha-D-2'-deoxyadenosine
Alpha-D-2'-deoxycytidine
Alpha-D-2'-deoxyguanosine
Alpha-D-thymidine
D: L-deoxy nucleosides
2-Amino-β-L-2'-deoxyadenosine
β-L-2'-deoxycytidine
β-L-2'-deoxydenosine
β-L-2'-deoxyguanosine
β-L-2'-deoxyuridine
β-L-thymidine
E: 7-deaza deoxy Nucleosides
7-Deaza-2'-deoxyadenosine
7-Deaza-2'-deoxyguanosine
7-Deaza-2'-deoxyInosine
F: N-Alkylated Nucleosides
N1-Methyl-2'-deoxyadenosine
N1-Methyl-2'-deoxyguanosine
N3-Methyl-2'-deoxycytidine
N3-Methyl-2'-deoxyuridine
N3-Methyl-thymidine
N4-Ethyl-2'-deoxycytidine
N4-Methyl-2'-deoxycytidine
N6-Methyl-2'-deoxyadenosine
G: Halogenated Nucleosides
5-Bromo-2'-deoxyuridine
5-Bromo-2'-deoxycytidine
5-Iodo-2'-deoxycytidine
5-Iodo-2'-deoxyuridine
7-Iodo-7-deaza-2'-deoxyadenosine
7-Iodo-7-deaza-2'-deoxyguanosine
8-Bromo-2'-deoxyadenosine
8-Bromo-2'-deoxyguanosine
H: Etheno Nucleosides
Etheno-2'-deoxyadenosine
Etheno-2'-deoxycytidine
I: Thio Nucleosides
4-Thio-2'-deoxyuridine
4-Thio-thymidine
6-Thio-2'-deoxyguanosine
J: 5-Alkyl Nucleosides
5-Methyl-2'-deoxycytidine
5-Propynyl-2'-deoxycytidine
5-Propynyl-2'-deoxyuridine
K: Modified Base Nucleosides
2'-Deoxynebularine; 2’-deoxy purine riboside
5-Aza-2'-deoxycytidine; 4-Amino-1-(2-deoxy-ß-D-ribofuranosyl)-1,3,5-triazin-2(1H)-one
L: Halogenated and deaza halogenated dideoxy Nucleosides
5-Iodo 2',3'-dideoxycytidine
5-Iodo-2',3'-dideoxyuridine
7-Deaza-2',3'-dideoxyadenosine
7-Deaza-2',3'-dideoxyguanosine
7-Iodo-7-deaza-2',3'-dideoxyadenosine
7-Iodo-7-deaza-2',3'-dideoxyguanosine
M: 8-Oxo & O6 substituted Guanosine
7-Deaza-O6-methyl-2'-deoxyguanosine
8-Oxo-2'-deoxyguanosine
O6-(Carboxymethyl)-2'-deoxyguanosine (Calcium Salt)
N: 3'-Levulinyl Nucleoside
3'-Levulinyl-2'-deoxyguanosine
O: 2'-Amino Nucleoside
2'-Amino-2'-deoxycytidine
P: Azido deoxy Nucleoside
3'-Azido-3’-deoxythymidine; Zidovudine; Retrovir
II-Unprotected ribo mononucleosides
A: Ribo Nucleosides
Adenosine
Cytidine
Guanosine
Inosine
Ribothymidine,  5-Methyl-ribouridine
Uridine
B: 2'-Fluoro deoxy nucleosides
2'-Fluoro-2'-deoxyadenosine
2'-Fluoro-2'-deoxycytidine
2'-Fluoro-2'-deoxyguanosine
2'-Fluoro-2'-deoxyuridine
C: L-ribo nucleosides
β-L-Adenosine
β-L-Cytidine
β-L-Guanosine
β-L-Inosine
β-L-Thymidine
β-L-Uridine
D: 7-Deaza ribo Nucleosides
7-Deaza-adenosine (Tubercidin)
7-Deaza-guanosine
7-Deaza-inosine
E: 2'-O-Methyl ribo nucleosides
2'-O-Methyl-adenosine
2'-O-Methyl-cytidine
2'-O-Methyl-guanosine
2'-O-Methyl-inosine
2'-O-Methyl-thymidine
2'-O-Methyl-uridine
F: 2'-O-Allyl ribo Nucleosides
2'-O-Allyl-adenosine
2'-O-Allyl-cytidine
2'-O-Allyl-guanosine
2'-O-Allyl-uridine
G: 2'-O-Propargyl ribo Nucleosides
2'-O-Propargyl-adenosine
2'-O-Propargyl-cytidine
2'-O-Propargyl-guanosine
2'-O-Propargyl-uridine
H: 3'-O-Methyl ribo Nucleosides
3'-O-Methyl-5-methyl-cytidine
3'-O-Methyl-adenosine
3'-O-Methyl-cytidine
3'-O-Methyl-guanosine
3'-O-Methyl-inosine
3'-O-Methyl-uridine
I: 3'-O-Allyl ribo Nucleosides
3'-O-Allyl-adenosine
3'-O-Allyl-cytidine
3'-O-Allyl-guanosine
3'-O-Allyl-uridine
J: 3'-O-Propargyl ribo Nucleosides
3'-O-Propargyl-adenosine
3'-O-Propargyl-cytidine
3'-O-Propargyl-guanosine
3'-O-Propargyl-uridine
K: 5',3'-Tetraisopropyl disiloxane ribo Nucleoside
5',3'-O-(1,1,3,3-Tetraisopropyl-1,3-disiloxanediyl)-Aadenosine
5',3'-O-(1,1,3,3-Tetraisopropyl-1,3-disiloxanediyl)-Cytidine
5',3'-O-(1,1,3,3-Tetraisopropyl-1,3-disiloxanediyl)-Guanosine
5',3'-O-(1,1,3,3-Tetraisopropyl-1,3-disiloxanediyl)-Uridine
L: Modified Base ribo Nucleosides
2,6-Diamino-Purine-riboside
2-Amino-Purine-riboside
M: 2,2’-Anhydro ribo Nucleosides
2,2'-O-Anhydro-5-methyl-cytidine
2,2'-O-Anhydro-cytidine (HCl Salt), (Beta-D-O-2,2’-Cyclocytidine Ancitabine)
2,2'-O-Anhydro-uridine (HCl Salt), (Beta-D-O-2,2’-Cyclouridine)
N: Etheno ribo  nucleosides
Etheno-adenosine
Etheno-cytidine
O: N-alkylated ribo  nucleosides
N3-Methyl-cytidine
N3-Methyl-uridine
N6-Dimethyl-adenosine
N6-Palmitoy-adenosine
P: 5-Alkyl ribo  nucleosides
5-Methyl-cytidine
5-Propynyl-cytidine
5-Propynyl-uridine
Q: Sustituted Ara Nucleosides
Ara-5-methyl-cytidine
Ara-7-deaza-guanosine
Uridine-arabinose
R: Thio Ribo Nucleosides
4'-Thio-uridine
8-Thio-guanosine
S: Halogenated ribo nucleosides
6-Chloro-inosine; 6-Chloropurine-riboside
5-Bromo-cytidine
5-Bromo-uridine
5-Iodo-cytidine
5-Iodo-uridine
7-Iodo-7-deaza-adenosine
8-Bromo-adenosine
8-Bromo-guanosine
T: Sustituted 2'-O-Methyl ribo nucleoside
2'-O-Methyl-5-iodo-uridine
2'-O-Methyl-5-methyl-cytidine
2'-O-Methyl-5-propynyl-cytidine
2'-O-Methyl-5-propynyl-uridine
2'-O-Methyl-N6-dimethyl-adenosine
β-L-2'-O-Methyl-2-amino-adenosine
β-L-2'-O-methyl-uridine
U: Sustituted 3'-O-Methyl ribo nucleoside
3'-O-Methyl-5-methyl-cytidine
V: Iso ribo nucleoside
Iso-2'-deoxyguanosine
Base (N-protected) mononucleosides
I-Base (N-protected) deoxy mononucleosides
A: Standard and Labile deoxy nucleosides
2'-Deoxyadenosine (N-Bz)
2'-Deoxyadenosine (N-DMF)
2'-Deoxyadenosine (N-PAC)
2'-Deoxycytidine (N-Ac)
2'-Deoxycytidine (N-Bz)
2'-Deoxycytidine (N-iBu)
2'-Deoxycytidine (N-PAC)
2'-Deoxyguanosine (N-DMF)
2'-Deoxyguanosine (N-iBu)
2'-Deoxyguanosine (N-PAC)
B: 5’-Levulinyl deoxy Nucleoside
5’-Levulinyl-2'-deoxyadenosine (N-Bz)
5’-Levulinyl-2'-deoxycytidine (N-Bz)
5’-Levulinyl-2'-deoxyguanosine (N-iBu)
5’-Levulinyl-2'-deoxythymidine
C: 3'-Levulinyl deoxy Nucleosides
3’-Levulinyl-2'-deoxyadenosine (N-Bz)
3’-Levulinyl-2'-deoxycytidine (N-Bz)
3’-Levulinyl-2'-deoxyguanosine (N-iBu)
3’-Levulinyl-2'-deoxythymidine
D: 3'-O-Acetyl deoxy Nucleosides
3’-O-Acetyl-2'-deoxyadenosine (N-Bz)
3’-O-Acetyl-2'-deoxycytidine (N-Bz)
3’-O-Acetyl-2'-deoxyguanosine (N-iBu)
3’-O-Acetyl-2'-deoxyuridine
3’-O-Acetyl-2'-thymidine
II-Base (N-protected) ribo mononucleosides
A: Standard and Labile ribo nucleosides
Aadenosine (N-isopentyl)
Adenosine (N-Bz)
Adenosine (N-PAC)
Cytidine (N-Ac)
Cytidine (N-Bz)
Cytidine (N-iBu)
Cytidine (N-PAC)
Guanosine (N-iBu)
Guanosine (N-PAC)
Guanosine (N-phenyl acetyl)
B: 5',3'-Tetraisopropyl disiloxane ribo Nucleoside
5',3'-O-(1,1,3,3-Tetraisopropyl-1,3-disiloxanediyl)-Adenosine (N-Bz)
5',3'-O-(1,1,3,3-Tetraisopropyl-1,3-disiloxanediyl)-Adenosine (N-iBu)
5',3'-O-(1,1,3,3-Tetraisopropyl-1,3-disiloxanediyl)-Cytidine  (N-Ac)
5',3'-O-(1,1,3,3-Tetraisopropyl-1,3-disiloxanediyl)-Cytidine (N-iBu)
5',3'-O-(1,1,3,3-Tetraisopropyl-1,3-disiloxanediyl)e-Adenosine (N-PAC)
5',3'-O-(1,1,3,3-Tetraisopropyl-1,3-disiloxanediyl)-Guanosine  (N-Ac)
5',3'-O-(1,1,3,3-Tetraisopropyl-1,3-disiloxanediyl)-Guanosine  (N-iBu)
5',3'-O-(1,1,3,3-Tetraisopropyl-1,3-disiloxanediyl)-Guanosine (N-DMF)
C: 2', 3'-isopropylene ribo nucleosides
2',3'-Isopropylidene-guanosine  (N-iBu)
2',3'-Isopropylidene-Adenosine (N-Bz)
2',3'-Isopropylidene-uridine
D: 2',3'-Diacetyl ribo Nucleosides
2',3'-Diacetyl-adenosine (N-Bz)
2',3'-Diacetyl-cytidine (N-Ac)
2',3'-Diacetyl-cytidine (N-Bz)
2',3'-Diacetyl-guanosine (N-iBu)
2',3'-Diacetyl-thymidine
2',3'-Diacetyl-uridine
E: Modified ribo Nucleosides (N-alkylated, 2,2’-Anhydro, 3’-(O-Allyl), 5-Methyl & Iso)
2,2’-Anhydro-5-methyl-cytidine (N-Bz)
3’-(O-Allyl)-cytidine (N-Bz)
5-Methyl-cytidine (N-Bz)
Adenosine (N-Ethyl)
Iso-guanosine (N-DBF)
DMT Protected mononucleoside
I-DMT Protected deoxy Mononucleoside
A: Deoxy mononucleosides with Standard and Labile protection
5'-O-DMTr-2'-deoxyadenosine (N6-t-Butyl-Phenoxy-Ac)
5'-O-DMTr-2'-deoxyadenosine (N-Ac)
5'-O-DMTr-2'-deoxyadenosine (N-Bz)
5'-O-DMTr-2'-deoxyadenosine (N-Fmoc)
5'-O-DMTr-2'-deoxyadenosine (N-iBu)
5'-O-DMTr-2'-deoxyadenosine (N-PAC)
5'-O-DMTr-2'-deoxycytidine (N4-t-Butyl-Phenoxy-Ac)
5'-O-DMTr-2'-deoxycytidine (N-Ac)
5'-O-DMTr-2'-deoxycytidine (N-Bz)
5'-O-DMTr-2'-deoxycytidine (N-Fmoc)
5'-O-DMTr-2'-deoxycytidine (N-iBu)
5'-O-DMTr-2'-deoxycytidine (N-PAC)
5'-O-DMTr-2'-deoxyguanosine (N-Fmoc)
5'-O-DMTr-2'-deoxyguanosine (N-iBu)
5'-O-DMTr-2'-deoxyguanosine (N-isopropyl-PAC)
5'-O-DMTr-2'-deoxyguanosine (N-PAC)
5'-O-DMTr-2'-deoxyguanosine (N-tBPAC)
5'-O-DMTr-2'-deoxyinosine
5'-O-DMTr-2'-deoxyuridine
5'-O-DMTr-Thymidine
B: 7-Deaza deoxy nucleosides
7-Deaza-5'-O-DMTr-deoxyadenosine (N-Bz)
7-Deaza-5'-O-DMTr-deoxyguanosine (N-iBu)
7-Deaza-5'-O-DMTr-deoxyinosine
C: Halogenated deoxy nucleosides
5-Bromo-5'-O-DMTr-deoxyuridine
5-Iodo-5'-O-DMTr-deoxycytidine (N-DBF)
5-Iodo-5'-O-DMTr-deoxyuridine
8-Bromo-5'-O-DMTr-deoxyadenosine (N-Bz)
8-Bromo-5'-O-DMTr-deoxyadenosine (N-DBF)
8-Bromo-5'-O-DMTr-deoxyguanosine (N-iBu)
D: 5-Alkylated deoxy nucleosides
5-Methyl-5'-O-DMTr-deoxycytidine (N-Bz)
5-Propynyl-5'-O-DMTr-deoxycytidine (N-Bz)
5-Propynyl-5'-O-DMTr-deoxyuridine
E: N-Alkylated deoxy Modified Nucleosides
N3-Methyl-5'-O-DMTr-thymidine
N6-Methyl-5'-O-DMTr-deoxyadenosine
N-Cyanoethyl-5'-O-DMTr-deoxycytidine
N3-Cyanoethyl-5'-O-DMTr-thymidine
G: Iso deoxy modified nucleoside
Iso-5'-O-DMTr-deoxyguanosine (N-DBF)
F: 3'-substituted deoxy modified nucleosides
3'-Azido-5'-O-DMTr-7-deaza-7-propargylamino (TFA)-2'-deoxyguanosine (N-PAC)
II-DMT Protected ribo Mononucleosides
A: ribo mononucleosides with Standard and Labile protection
5'-O-DMTr-Adenosine (N-Bz)
5'-O-DMTr-Adenosine (N-Fmoc)
5'-O-DMTr-Adenosine (N-PAC)
5'-O-DMTr-Cytidine (N-Ac)
5'-O-DMTr-Cytidine (N-Bz)
5'-O-DMTr-Cytidine (N-Fmoc)
5'-O-DMTr-Cytidine (N-iBu)
5'-O-DMTr-Cytidine (N-PAC)
5'-O-DMTr-Guanosine (N-Ac)
5'-O-DMTr-Guanosine (N-Fmoc)
5'-O-DMTr-Guanosine (N-iBu)
5'-O-DMTr-Guanosine (N-isopropyl-PAC)
5'-O-DMTr-Guanosine (N-PAC)
5'-O-DMTr-Inosine
5'-O-DMTr-Thymidine
5'-O-DMTr-Uridine
B:  2'-O-Methyl ribo nucleosides
2'-O-Methyl-5'-O-DMTr-adenosine (N-Bz)
2'-O-Methyl-5'-O-DMTr-adenosine (N-PAC)
2'-O-Methyl-5'-O-DMTr-cytidine (N-Ac)
2'-O-Methyl-5'-O-DMTr-cytidine (N-Bz)
2'-O-Methyl-5'-O-DMTr-cytidine (N-PAC)
2'-O-Methyl-5'-O-DMTr-guanosine (N-iBu)
2'-O-Methyl-5'-O-DMTr-guanosine (N-PAC)
2'-O-Methyl-5'-O-DMTr-uridine
C: 2'-O-TBDMS  ribo modified nucleosides
2'-O-TBDMS-5'-O-DMTr-adenosine (N-diBz)
2'-O-TBDMS-5'-O-DMTr-adenosine (N-Bz)
2'-O-TBDMS-5'-O-DMTr-adenosine (N-PAC)
2'-O-TBDMS-5'-O-DMTr-cytidine (N-Ac)
2'-O-TBDMS-5'-O-DMTr-cytidine (N-Bz)
2'-O-TBDMS-5'-O-DMTr-cytidine (N-PAC)
2'-O-TBDMS-5'-O-DMTr-guanosine (N-DMF)
2'-O-TBDMS-5'-O-DMTr-guanosine (N-iBu)
2'-O-TBDMS-5'-O-DMTr-guanosine (N-iPrPAC)
2'-O-TBDMS-5'-O-DMTr-guanosine (N-PAC)
2'-O-TBDMS-5'-O-DMTr-inosine
2'-O-TBDMS-5'-O-DMTr-uridine
D: 3'-O-TBDMS  ribo modified nucleosides
3'-O-TBDMS-5'-O-DMTr-Adenosine (N-Bz)
3'-O-TBDMS-5'-O-DMTr-Cytidine (N-Bz)
3'-O-TBDMS-5'-O-DMTr-Guanosine (N-iBu)
3'-O-TBDMS-5'-O-DMTr-Uridine
3'-O-TBDMS-5'-O-DMTr-Cytidine (N-Ac)
E: 2’-O-Methyl-5-Alkylated ribo nucleosides
2'-O-Methyl-5-methyl-5'-O-DMTr-cytidine (N-Bz)
2'-O-Methyl-5-methyl-5'-O-DMTr-uridine
2'-O-Methyl-5-propynyl-5'-O-DMTr-cytidine (N-Bz)
2'-O-Methyl-5-propynyl-5'-O-DMTr-uridine
F: 5-Alkylated ribo modified nucleosides
5-Methyl-5'-O-DMTr-cytidine (N-Bz)
5-Propynyl-5'-O-DMTr-cytidine (N-Bz)
5-Propynyl-5'-O-DMTr-uridine
G: Modified purine ribo nucleosides
5'-O-DMTr-Purine-riboside (N6-DMF) (N2-iBu)
H: Halogenated ribo nucleosides
8-Bromo-5'-O-DMTr-adenosine (N-DBF)